The biophysics of fungal mycotoxemia: How luminal polymeric toxin adsorbents intercept fungal peptides before systemic vascular absorption.
1. Candidalysin Peptides and Dermal Micro-Capillary Damage
Candidalysin is a pore-forming peptide toxin synthesized exclusively by hyphal forms of Candida albicans. Once translocated into bloodstream circulation, these hydrophobic peptides intercalate into endothelial cell membranes lining dermal micro-capillaries, inducing micro-vascular inflammation (dermal vasculitis).
2. Luminal Polymeric Adsorption and Toxin Interception
Polymeric humic and fulvic organic complexes possess high ion-exchange capacity and porous surface topology. In the intestinal lumen, these complexes electrostatically bind Candidalysin peptides, preventing their mucosal absorption and promoting safe fecal elimination.
3. Reference Index
Literature references: PubMed PMID: 42073497; PubMed PMID: 40547444.
References
- PubMed PMID: 42073497 — Candidalysin Pore-Forming Mechanics and Endothelial Vasculitis.
- PubMed PMID: 40547444 — Polymeric Organic Humic Substances as High-Affinity Peptidic Binders.
Academic Sources & Direct Database Links
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Last Updated: February 01, 2026
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